To validate the efficacy of Powergrape^®, Naturex performed several scientific studies on its extract:

TYPE OF STUDY	RESULTS	CONCLUSION
In vitro study	Antioxidant capacity ORAC= 14.593 µmol TE*/g Antioxidant capacity FRAP =	Powergrape® has high antioxidant capacity in vitro.
Prospective, double blind clinical study	% variation after vs before Powergrape® Antioxidant protection - Ubiquinone concentrations = +96% - Vit C* concentrations  = +60% - Vit C/Vit E* ratio = +61% - Lipophilic antioxidant capacity = +14%	Taking 400 mg of Powergrape® per day for 21 days as a supplement improved the antioxidant status of the volunteers.
Randomized, cross-over, double-blind clinical trial against placebo	% variation Powergrape® vs placebo Antioxidant protection - Plasma vit E concentrations: +4.1% - Plasma GPx* concentrations = +6.3% - Plasma ORAC* value: +9.9% - Plasma FRAP* value: +7.7% Cellular oxygenation - Hemoglobin concentration: + 3.6% Muscle protection - CpK* concentration: -100.9% - Urinary isoprostane concentration: -48.8% Tonic action - Performance: +23.9% - Recovery: +7.9%	Powergrape® (400 mg per day for 30 days) improves performance and RECOVERY by: - increasing oxygenation of the muscles; - protecting the muscles against lesions caused by physical exercise; - improving the individual's antioxidant status.
Randomized, cross-over, double-blind clinical trial against placebo	Iron status - Plasma ferritin concentration: no significant reduction - Plasma hemoglobin concentration:  no significant reduction	Taking 400 mg/day of Powergrape® does not affect the individual's iron status.
* TE: Trolox® équivalent; Vit C: vitamin C; Vit E: vitamin E; GPx: glutathion peroxydase; ORAC: oxygen radical absorbance capacity; FRAP: ferric reducing antioxidant power; CPK: creatine phosphokinase

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